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4,4-Dimethylpiperidine → 4-(4,4-Dimethylpiperidin-1-yl)-2-(3-chlorobenzyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,4-Dimethylpiperidine | HCID 138100 | — |
| 反応物 | 2-(3-Chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | HCID 58407802 | — |
| 生成物 | 4-(4,4-Dimethylpiperidin-1-yl)-2-(3-chlorobenzyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile | HCID 135995032 | — |
反応手順
In analogy to the preparation of Example 1, 150 mg (0.51 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 582 mg (5.14 mmol) of 4,4-dimethylpiperidine to give 96 mg (52% of theory) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08088769B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-3a2af563e55642549d5e7367ca025bfe |
| 出典メモ | uspto-grants-2012_01 |