Hydrochloric Acid → HCID 68817634、化合物

HRID 41498

反応式

HRID 41498 の反応式
CS(C)=O.[ClH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]>CC(O)C>[ClH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 679Dimethyl Sulfoxide2 回HCID 66646296methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid

生成物 1

HCID 68817634HCID 68817634、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Dimethyl sulfoxide (1 mL) and hydrochloric acid (22 μL) were added to methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid (99.37 mg). Dimethyl sulfoxide (2 mL) was added to and dissolved in the mixture while heating the mixture, 2-propanol (3 mL) was added to the mixture, and the mixture was cooled to room temperature to be solidified. The solid was collected by filtration to yield the titled compound (88.65 mg).

後処理

  1. dissolutiondissolved in the mixture
  2. additionwas added to the mixture
  3. filtrationThe solid was collected by filtration

出典と根拠

ORDレコード
ord-d69699ced6d04373b7ba39101758b8fe
出典データセット
uspto-grants-2013_09
特許番号
US08530654B2

関連ノート

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