関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 1,2,3-Triazine | HCID 123047 | — |
| 反応物 | 2-Amino-5-hydroxy-4-methoxybenzoic acid | HCID 19807028 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 178486868 | HCID 178486868 | 107.1% |
反応手順
Piperidine (3 mL, 31 mmol) was added to a mixture of 2-Amino-5-hydroxy-4-methoxy-benzoic acid (8.1 g, 44.26 mmol) and triazine (5.38 g, 66.4 mmol) in MeOH (60 mL). The reaction was then heated to reflux and stir for 6 hours. The reaction was cool to 0° C. The product was isolated by filtration and washed with cold MeOH to give 6.37 g (33.2 mmol, 75%) of desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08088766B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-f0d62225581f45c8a0294bae9c5fb353 |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
