Azanium;hydrate → 4-Methoxyphenylbenzo[d]oxazole-4-carboxamide
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([O-:20])=O)[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1.O.[NH4+:22]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([NH2:22])=[O:20])[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1参加物
3
実験手順
Methyl 2-(4-methoxyphenylbenzo[d]oxazole-4-carboxylate (68 mg, 0.24 mmol) in ammonium water (10 mL) was stirred at 30° C. overnight, then filtered, and the cake was washed with water, dried in vacuum to obtain 2-(4-methoxyphenylbenzo[d]oxazole-4-carboxamide (29 mg, yield 45%). 1H-NMR (400 MHz, DMSO-d6) δ 3.88 (s, 3H), 7.17-7.19 (d, J=8 Hz, 1H), 7.49 (dd, 1H), 7.94-7.97 (m, 3H), 8.25-8.26 (d, J=8 Hz, 2H), 8.49 (brs, 1H); LC-MS (ESI) m/z 269 [M+1]−.
後処理
- filtrationfiltered
- washthe cake was washed with water
- customdried in vacuum