関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Heptanal | HCID 8130 | — |
| 反応物 | Benzene, 1,3-dibromo-2-methoxy- | HCID 181584 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (RS)-2-bromo-6-(1-hydroxyheptyl)anisole | HCID 59544889 | 79% |
反応手順
To a THF solution of 2,6-dibromoanisole (10 g, 37.6 mmol) was added Mg (0.90 g, 37.6 mmol), and the mixture was heated and stirred at 40° C. Under ice-cooling, n-heptanal (47.2 g, 41.3 mmol) was added dropwise. Aqueous hydrochloric acid solution was added to the reaction mixture, this was extracted with ethyl acetate, and the solvent was distilled off to obtain 8.95 g of a compound (1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08530668B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-0586628f68394c568875f29b5148eba6 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
