5-Methylisoxazole-3-carbonyl chloride → 6-(2-Fluoro-4-iodophenylamino)-1,3-dimethyl-5-(5-methylisoxazole-3-carbonyl)pyrimidine-2,4(1H,3H)-dione
反応式
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:15]([CH3:16])[C:14](=[O:17])[N:13]([CH3:18])[C:12](=[O:19])[C:11]=1[C:20](OC1C=CC=CC=1)=[O:21].[CH3:29][C:30]1[O:34][N:33]=[C:32](C(Cl)=O)[CH:31]=1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:15]([CH3:16])[C:14](=[O:17])[N:13]([CH3:18])[C:12](=[O:19])[C:11]=1[C:20]([C:32]1[CH:31]=[C:30]([CH3:29])[O:34][N:33]=1)=[O:21]参加物
3
実験手順
The title compound was synthesized following a similar procedure described in the synthesis of compound 2A by reaction of Example 1 and 5-methylisoxazole-3-carbonyl chloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.42 (s, 2H) 3.13 (s, 2H) 3.19 (s, 2H) 6.13-6.29 (m, 1H) 7.08 (t, J=8.59 Hz, 1H) 7.47 (dd, J=8.46, 1.89 Hz, 1H) 7.68 (dd, J=9.98, 1.89 Hz, 1H) 10.47 (s, 1H) [M+H] calc'd for C17H14FIN4O4, 485; found, 485.