4-Methylsulfanyl-2-nitro-benzoic acid methyl ester → Methyl 2-amino-4-(methylthio)benzoate
反応式
[CH3:1][S:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([N+:13]([O-])=O)[CH:4]=1.[H][H]>C(OC)(=O)C.[Pt]=S>[NH2:13][C:5]1[CH:4]=[C:3]([S:2][CH3:1])[CH:12]=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8]参加物
5
実験手順
A mixture of methyl 4-(methylthio)-2-nitrobenzoate (11.3 g, 49.7 mmol) and 5% platinum sulfide on carbon catalyst (0.7 g) in methyl acetate (40 mL) was hydrogenated at 750 psi and 75° C. until hydrogen uptake ceased. The mixture was filtered through Celite®, and the filtrate solvent was rotary evaporated, leaving methyl 2-amino-4-(methylthio)benzoate as a slightly tan crystalline solid (8.7 g) melting at 57°-59° C.
後処理
- filtrationThe mixture was filtered through Celite®
出典と根拠
- ORDレコード
- ord-efea6328e97c41fda837d753a6815718
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04724039
反応ノート
読み込み中…