Triethylamine → 2,5-dichloro-N-(5-methoxy-1H-pyrazol-3-yl)pyrimidin-4-amine

HRID 415427ノート

反応式

HRID 415427 の反応式
[CH3:1][O:2][C:3]1[NH:7][N:6]=[C:5]([NH2:8])[CH:4]=1.C(N(CC)CC)C.[Cl:16][C:17]1[N:22]=[C:21](Cl)[C:20]([Cl:24])=[CH:19][N:18]=1>CCO>[Cl:16][C:17]1[N:22]=[C:21]([NH:8][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[NH:7][N:6]=2)[C:20]([Cl:24])=[CH:19][N:18]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 2372592,4,5-TrichloropyrimidineHCID 178493288HCID 178493288、化合物

生成物 1

HCID 1784930722,5-dichloro-N-(5-methoxy-1H-pyrazol-3-yl)pyrimidin-4-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 5-methoxy-1H-pyrazol-3-amine (890 mg, 7.8 mmol) in absolute EtOH (20 ml) was added triethylamine (3.3 ml, 23.6 mmol) and 2,4,5-trichloropyrimidine (1.4 g, 7.8 mmol) and the resulting solution was aged at room temperature for 12 hours. The mixture was partitioned between EtOAc and H2O, the organic layer was washed with brine and dried. The solvents were removed under reduced pressure to give the title compound as an oil which crystallized upon standing (1.8 g). m/z: 261.

後処理

  1. customThe mixture was partitioned between EtOAc and H2O
  2. washthe organic layer was washed with brine
  3. customdried
  4. customThe solvents were removed under reduced pressure

出典と根拠

ORDレコード
ord-12429812cce247c59750ceefeb7103e9
出典データセット
uspto-grants-2012_01
特許番号
US08088784B2

反応ノート

読み込み中…