2,4,5,6-Tetrachloropyrimidine → HCID 178493073、化合物

HRID 415441

反応式

HRID 415441 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]([Cl:9])=[C:4](Cl)[N:3]=1.Cl.[CH3:12][O:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([NH:19][C:16]2[CH:15]=[C:14]([O:13][CH3:12])[NH:18][N:17]=2)[C:5]([Cl:9])=[C:6]([Cl:8])[N:7]=1

参加物

4

反応物 2

HCID 156902,4,5,6-TetrachloropyrimidineHCID 178493289HCID 178493289、化合物

生成物 1

HCID 178493073HCID 178493073、化合物収率 25.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 2,4,5,6-tetrachloro-pyrimidine (2.18 g) in absolute ethanol (100 mL) was added DIEPA (4.4 mL) and 5-methoxy-1H-pyrazol-3-amine hydrogen chloride salt (1.50 g). The resulting solution was stirred at room temperature for over night. The solvent was evaporated under reduced pressure. The crude compound was purified by Gilson (10-60% MeCN/H2O, 15 minutes) to give the titled compound as solid (0.76 g). m/z 294.

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. customThe crude compound was purified by Gilson (10-60% MeCN/H2O, 15 minutes)

出典と根拠

ORDレコード
ord-31b3bb9ac5eb443390e029345ae3ca5f
出典データセット
uspto-grants-2012_01
特許番号
US08088784B2

関連ノート

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