2-Amino-6-methylbenzothiazole → 2,6-Difluoro-3-[(6-methyl-1,3-benzothiazol-2-yl)methoxy]benzenecarboxamide

反応式

[CH3:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7](N)[S:8][C:4]=2[CH:3]=1.C([CH2:14][O:15][C:16]1[C:17]([F:26])=[C:18]([C:23]([NH2:25])=[O:24])[C:19]([F:22])=[CH:20][CH:21]=1)#N>>[F:26][C:17]1[C:16]([O:15][CH2:14][C:7]2[S:8][C:4]3[CH:3]=[C:2]([CH3:1])[CH:11]=[CH:10][C:5]=3[N:6]=2)=[CH:21][CH:20]=[C:19]([F:22])[C:18]=1[C:23]([NH2:25])=[O:24]

参加物

反応物 2

HCID 173352-Amino-6-methylbenzothiazole

HCID 594028043-(Cyanomethoxy)-2,6-difluorobenzenecarboxamide

生成物 1

HCID 462372682,6-Difluoro-3-[(6-methyl-1,3-benzothiazol-2-yl)methoxy]benzenecarboxamide収率 17%

実験手順

Synthesised from 6-methyl-1,3-benzothiazol-2-amine and 3-(cyanomethoxy)-2,6-difluorobenzene carboxamide, according to Method K, scheme 26. Yield 17% (second step), HPLC-MS (method 1): m/z 335 [M+H]+, Rt=3.70 min.

出典と根拠

ORDレコード: ord-05ae5082ea0646049d140347e5df9264
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08088791B2

反応ノート

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