3-Chloro-2-butanone → 2-(4-Methoxy-phenyl)-4,5-dimethyl-oxazole

HRID 415644ノート

反応式

HRID 415644 の反応式
Cl[CH:2]([CH3:6])[C:3](=O)[CH3:4].[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][CH:10]=1>>[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]2[O:14][C:2]([CH3:6])=[C:3]([CH3:4])[N:15]=2)=[CH:11][CH:10]=1

参加物

3

反応物 2

HCID 200263-Chloro-2-butanoneHCID 769594-Methoxybenzamide

生成物 1

HCID 189829612-(4-Methoxy-phenyl)-4,5-dimethyl-oxazole収率 83.6%

反応条件

温度
115 °C

実験手順

A mixture of 3-Chloro-2-butanone (2.1 g, 10.0 mmol) and 4-methoxybenzamide (0.30 g, 1.0 mmol) was heated at 115° C. for 15 h under nitrogen atmosphere. After the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure and the residue was purified over silica gel (230-400 M, 20% EtOAc-Hexane) to get the desired product (0.17 g, 42%) as a white solid. The corresponding chloro derivative was also prepared by the same general method.

後処理

  1. customAfter the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure
  2. customthe residue was purified over silica gel (230-400 M, 20% EtOAc-Hexane)

出典と根拠

ORDレコード
ord-4e6f58dfdbb14c099a1365cfb18d06ec
出典データセット
uspto-grants-2012_01
特許番号
US08088791B2

反応ノート

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