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HRID 415699作成日：2026年10月26日
Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → (S,E)-tert-butyl 4-(3-ethoxy-3-oxoprop-1-enyl)-2,2-dimethyloxazolidine-3-carboxylate
https://huagongshe.com/reaction/415699
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| 反応物 | 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- | HCID 178792 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | (S,E)-tert-butyl 4-(3-ethoxy-3-oxoprop-1-enyl)-2,2-dimethyloxazolidine-3-carboxylate | HCID 10732902 | 111.3% |
反応手順
A mixed solution comprising (4R)-4-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylic acid tert-butyl ester (11.7 g), (carboethoxymethylene)triphenylphosphorane (20.7 g) and toluene (100 ml) was heated with stirring at 100° C. for 18 hours. The reaction mixture was concentrated, and the resulting residue was purified by silica gel column chromatography (hexane:acetic acid ethyl ester=8:1), to obtain the title compound (17 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08088796B2 |
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| 出典データセット | uspto-grants-2012_01 |
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| ORD ID | ord-981112ebcf974b618030a67fa482d260 |
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| 出典メモ | uspto-grants-2012_01 |
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