4-Amino-5-iodo-2-(trifluoromethyl)benzonitrile → 4-Amino-5-cyano-2-trifluoromethyl-benzonitrile
反応式
[NH2:1][C:2]1[C:9](I)=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.[C:15]([Cu])#[N:16]>CN1C(=O)CCC1>[NH2:1][C:2]1[CH:3]=[C:4]([C:11]([F:14])([F:13])[F:12])[C:5]([C:6]#[N:7])=[CH:8][C:9]=1[C:15]#[N:16]参加物
4
実験手順
4-Amino-5-iodo-2-trifluoromethyl-benzonitrile (1.5 mmoL), CuCN (1.7 mmoL) in NMP (10 mL) was heated at 150° C. for 4 hrs. The reaction mixture was passed through a pad of Celite. The reaction mixture was then partitioned between ethyl acetate and water. The organic layer was washed with water, then brine, dried over anhydrous Na2SO4, filtered and concentrated to yield the title compound as a brown solid.
後処理
- customThe reaction mixture was then partitioned between ethyl acetate and water
- washThe organic layer was washed with water
- dry with materialbrine, dried over anhydrous Na2SO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-b56a3338f3874626bcdb1c66268405ee
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08088811B2
反応ノート
読み込み中…