Water → 2-Aminocarbonylamino-4-chloro-5-(2-naphthyl)pyrrole-3-carboxamide

HRID 416030ノート

反応式

HRID 416030 の反応式
[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)=[CH:8][C:9]=1[C:10]([NH2:12])=[O:11])=[O:3].[Cl:23]N1C(=O)CCC1=O.O>CN(C)C=O>[NH2:1][C:2]([NH:4][C:5]1[NH:6][C:7]([C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)=[C:8]([Cl:23])[C:9]=1[C:10]([NH2:12])=[O:11])=[O:3]

参加物

5

反応物 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 461809882-Aminocarbonylamino-5-(2-naphthyl)pyrrole-3-carboxamide

生成物 1

HCID 582940372-Aminocarbonylamino-4-chloro-5-(2-naphthyl)pyrrole-3-carboxamide収率 45%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 2-aminocarbonylamino-5-(2-naphthyl)pyrrole-3-carboxamide (Compound No. 1-1, 92 mg, 0.31 mmol) and N-chlorosuccinimide (46 mg, 0.34 mmol) in anhydrous N,N-dimethylformamide (2 mL) was stirred at 60° C. for 2 hours. After cooling, water (10 mL) was added thereto, the precipitated solid was filtered off, and washed with water (10 mL) and acetone (10 mL). The obtained solid was dried at 50° C. under reduced pressure to give the target compound (46 mg) as a pale brown solid (Yield 45%).

後処理

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid was filtered off
  3. washwashed with water (10 mL) and acetone (10 mL)
  4. customThe obtained solid was dried at 50° C. under reduced pressure

出典と根拠

ORDレコード
ord-1cf96be556f44b5ba843c18e3f773bd9
出典データセット
uspto-grants-2012_01
特許番号
US08088817B2

反応ノート

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