Trifluoroacetic acid → 1-(5-(4-Bromophenyl)thien-2-yl)-3-(2,3-dichloro-4-hydroxyphenyl)propan-1-one

関与物質

反応手順

1-(5-(4-Bromophenyl)thien-2-yl)-3-(2,3-dichloro-4-hydroxyphenyl)prop-2-en-1-one is dissolved in dichloromethane (0.7 g, 1.5 mol/L). Triethylsilane (2.1 eq.) and trifluoroacetic acid (8 eq.) are successively added dropwise. After stirring for 16 hours at room temperature, the reaction mixture is washed with water and then the dichloromethane is removed by evaporation under reduced pressure. The evaporation residue is purified by silica-gel chromatography

情報源と証拠