Morpholine → 1-[6-(Morpholin-4-yl)pyridin-3-yl]ethan-1-one

HRID 416229

反応式

Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CCO>[N:11]1([C:2]2[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=2)[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

参加物

実験手順

A solution of 32 (1.25 g, 7.9 mmol) and morpholine (2.20 mL, 25.2 mmol) in EtOH (22 mL) was refluxed for 12 h and then evaporated to dryness. The residue was dissolved in EtOAc (200 mL), washed with saturated NaHCO3 (50 mL×2) and brine (50 mL), dried over Na2SO4, filtered and evaporated to afford the title compound 33a (1.66 g, quantitative yield) as a pale yellow solid.

後処理

customevaporated to dryness
dissolutionThe residue was dissolved in EtOAc (200 mL)
washwashed with saturated NaHCO3 (50 mL×2) and brine (50 mL)
dry with materialdried over Na2SO4
filtrationfiltered
customevaporated

出典と根拠

ORDレコード: ord-7a51bdd3b1294f3386219cf986721fc0
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08088805B2

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

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