Morpholine → 4-(6-Chloropyridazin-3-yl)morpholine

HRID 416235ノート

反応式

HRID 416235 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=1>>[Cl:7][C:8]1[N:9]=[N:10][C:11]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[CH:12][CH:13]=1

参加物

3

反応物 2

HCID 8083MorpholineHCID 673313,6-Dichloropyridazine

生成物 1

HCID 3210794-(6-Chloropyridazin-3-yl)morpholine収率 79.1%

反応条件

温度
90 °C

実験手順

A 50 mL flask equipped with a reflux condenser was charged with morpholine (2.93 mL, 33.5 mmol) and 3,6-dichloropyridazine (5.00 g, 33.5 mmol). The mixture was heated at 90° C. for 6 h, the resultant solid was partitioned between EtOAc, water and saturated NH4Cl. Organic layer was separated, dried over anhydrous Na2SO4, filtered, and evaporated to afford the title compound 64 (5.3 g, 26.5 mmol, 79% yield).

後処理

  1. customA 50 mL flask equipped with a reflux condenser
  2. customthe resultant solid was partitioned between EtOAc, water and saturated NH4Cl
  3. customOrganic layer was separated
  4. dry with materialdried over anhydrous Na2SO4
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-347ec66b98f74d89a732af63a249016c
出典データセット
uspto-grants-2012_01
特許番号
US08088805B2

反応ノート

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