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3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one → 4-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one | HCID 5369165 | — |
| 反応物 | (E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one | HCID 5825354 | — |
| 反応物 | 4-[(4-Pyrazin-2-yl-pyrimidin-2-ylamino)-methyl]-benzoic acid | HCID 66622167 | — |
| 反応物 | HCID 178512548 | HCID 178512548 | — |
| 生成物 | 4-(4-(Pyridin-3-yl)pyrimidin-2-ylamino)benzoic acid | HCID 14346970 | — |
反応手順
Title compound was prepared according to the procedure described for the synthesis of compound 25a (scheme 6, step 3) replacing the guanindine 24 by 4-guanidinobenzoic acid (344) (Zlatoidsky P., Maliar T. Eur. J. Med. Chem Chim. Ther.; 1996, 31, 895-900) and (E)-3-(dimethylamino)-1-(pyrazin-2-yl)-prop-2-en-1-one (23a) by (E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one (345) (Zimmermann J., Buchdunger E., et al. Bioorg. Med. Chem. Lett., 1996, 6, 1221-1226). Yield of the product 28%. MS (m/z): 292.29 (calc) 293.1 (MH+) (found).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08088805B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-aee82466963b472296b51e3e048c19ac |
| 出典メモ | uspto-grants-2012_01 |