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Triethylamine → tert-Butyl 2-(5-formylthiophene-2-carboxamido)phenylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| 反応物 | N-(tert-Butoxycarbonyl)-1,2-phenylenediamine | HCID 676311 | — |
| 反応物 | 5-Formyl-2-thiophenecarboxylic Acid | HCID 818882 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | tert-Butyl 2-(5-formylthiophene-2-carboxamido)phenylcarbamate | HCID 58930645 | 33.5% |
反応手順
A solution of 5-formylthiophene-2-carboxylic acid (350 mg, 2.24 mmol), tert-butyl 2-aminophenylcarbamate (467 mg, 2.24 mmol) and triethylamine (470 μL, 340 mg, 3.36 mmol) and BOP (1.1 g, 2.68 mmol) in DMF (10 mL) was stirred at room temperature for 2 hours. The reaction mixture was concentrated and purified by flash chromatography using 25% EtOAc in hexanes as an eluent, yielding 260 mg (33%) of the title compound. 1H NMR (CDCl3) 9.95 (s, 1H), 9.7 (br. s, 1H), 7.84 (d, 1H, J=8.0 Hz), 7.74 (m, 2H), 7.15 (m, 2H), 6.72 (s, 1H), 1.56 (s, 9H). LRMS: (calc) 346.1; (found) 369.1 (M+Na)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08088805B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-ee460b9b649d4ae1a10c3f119c93cbb9 |
| 出典メモ | uspto-grants-2012_01 |