Bromoacetic Acid → HCID 178418509、化合物

HRID 4163

反応式

HRID 4163 の反応式
[SH:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1.[OH-].[K+].Br[CH2:11][C:12]([OH:14])=[O:13]>O>[C:12]([CH2:11][S:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1)([OH:14])=[O:13]

参加物

5

反応物 3

HCID 6227Bromoacetic AcidHCID 14797Potassium HydroxideHCID 178418558HCID 178418558、化合物

生成物 1

HCID 178418509HCID 178418509、化合物収率 86.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
60 °C

実験手順

In 200 ml of water were dissolved 15.0 g of 2,5-dimercapto-1,3,4-thiadiazole and 69 g of potassium hydroxide, and a solution of 13.9 g of bromoacetic acid in 30 ml of water was added thereto dropwise at room temperature. After the addition, the mixture was stirred at 60° C. for 1 hour, followed by allowing to cool to room temperature. The precipitated crystals were filtered and washed with water to obtain 18 g of the desired compound. Melting point: 161°-167° C.

後処理

  1. customdropwise at room temperature
  2. additionAfter the addition
  3. temperatureto cool to room temperature
  4. filtrationThe precipitated crystals were filtered
  5. washwashed with water

出典と根拠

ORDレコード
ord-03c19910184945d28d0037efcffa7194
出典データセット
uspto-grants-1988_02
特許番号
US04724199

関連ノート

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