Hydrazine → Isoquinoline-3-carbohydrazide

HRID 416315

反応式

HRID 416315 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13]C)=O)[N:2]=1.[NH2:15][NH2:16]>C(O)C>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([NH:15][NH2:16])=[O:13])[N:2]=1

参加物

4

反応物 2

HCID 9321HydrazineHCID 725374Methyl 3-isoquinolinecarboxylate

生成物 1

HCID 55263898Isoquinoline-3-carbohydrazide収率 86%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of methyl isoquinoline-3-carboxylate (10 g, 53.42 mmol) in ethanol (100 mL) was added hydrazine (17.1 g). The reaction mixture was refluxed for 30 min and concentrated under high vacuum to remove hydrazine. The resulting residue was triturated with ethanol (20 mL) to give isoquinoline-3-carbohydrazide (8.6 g, 86%). LRMS (M+H+) m/z 188.1.

後処理

  1. temperatureThe reaction mixture was refluxed for 30 min
  2. concentrationconcentrated under high vacuum
  3. customto remove hydrazine
  4. customThe resulting residue was triturated with ethanol (20 mL)

出典と根拠

ORDレコード
ord-c74fdf04e1aa41209ea2a44cffdbc2bf
出典データセット
uspto-grants-2012_01
特許番号
US08088793B2

関連ノート

読み込み中…