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Iodine → 2-Iodo-6-methylpyridin-3-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2-Methyl-5-hydroxypyridine | HCID 14275 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Iodo-6-methylpyridin-3-ol | HCID 89957 | 43.9% |
反応手順
Sodium carbonate (68.0 g) and water (810 mL) were added to 5-hydroxy-2-methylpyridine (1-014-01) (36.11 g), and the reaction mixture was stirred at room temperature, dissolved. To the reaction mixture was added dropwise a solution of iodine (117 g) and potassium iodide (117 g) in water (810 mL) for 35 min. The resulting pink-yellow crystal was filtered and dried under reduced pressure to give 2-iodo-3-hydroxy-6-methylpyridine (2-014-01) (34.1 g, 43.9%, m.p. 187-190° C.)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08088924B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-a2e97d959c4e4dd8b6b848baa7230577 |
| 出典メモ | uspto-grants-2012_01 |