関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Amino-3-Hydroxypyridine | HCID 28114 | — |
| 反応物 | 5-Aminonicotinic Acid | HCID 354316 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-Oxazolo[4,5-b]pyridin-2-yl-pyridin-3-ylamine | HCID 59679866 | — |
反応手順
In a typical run, 790 mg of 2-amino-3-hydroxypyridine (7.24 mmol) and 1.00 g of 5-aminonicotinic acid (7.24 mmol) were mixed with 10 mL of PPA and stirred at 200° C. for 6 hours. The reaction mixture was cooled to about 100° C. and carefully poured into 100 mL of water. The pH was brought to 6 with solid NaOH and the solids were collected by filtration. After drying under high vacuum, a total of 180 mg of 5-oxazolo[4,5-b]pyridin-2-yl-pyridin-3-ylamine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08088928B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-1202477142d14cb88eaaec556cc7deab |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
