Hydrochloric Acid → L-Cysteine hydrochloride monohydrate

温度

-10 °C

500 ml of a purified L-cysteine-containing solution (eluate with 1N HCl) of example 7 or 9 (L-cysteine content=17 g/l) are concentrated to 25 ml. After adding concentrated HCl or introducing HCl gas, chlorides of inorganic alkali metal and alkaline earth metal ions and ammonium chloride may be crystallized, preferably at 20-60° C. After filtration, the L-cysteine-containing mother liquor is cooled to −10° C. and L-cysteine hydrochloride monohydrate crystallizes. Depending on the purity of the L-cysteine-containing solution used, L-cysteine hydrochloride monohydrate may be obtained in crystalline form in yields of >80% and purities of >90% from these solutions. It is possible to achieve purities of up to >98% by suitable control of the crystallization conditions, fractionated crystallization and/or recrystallization.

1. concentrationare concentrated to 25 ml
2. additionAfter adding concentrated HCl
3. additionintroducing HCl gas, chlorides of inorganic alkali metal and alkaline earth metal ions and ammonium chloride
4. custommay be crystallized, preferably at 20-60° C
5. filtrationAfter filtration
6. additionthe L-cysteine-containing mother liquor
7. customL-cysteine hydrochloride monohydrate crystallizes
8. additioncontaining solution

ORDレコード

ord-25b21d06295f4ec6a1f72a2e675fa149

出典データセット

uspto-grants-2012_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08088949B2