関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Magnesium Carbonate | HCID 11029 | — |
| 反応物 | Chloromalonaldehyde | HCID 147646 | — |
| 反応物 | 4-Bromo-2-methylthiobenzamide | HCID 45040716 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | 2-(4-Bromo-2-methyl-phenyl)-thiazole-5-carbaldehyde | HCID 59584621 | 99.8% |
反応手順
To a suspension of 4-bromo-2-methyl-thiobenzamide (3.11 g, 13.5 mmol) and 2-chloromalonaldehyde (2.16 g, 20.3 mmol) in dimethoxyethane (20 ml) is added magnesium carbonate (567 mg, 6.75 mmol) and the resulting mixture stirred at 60° C. under N2 for 3 hours. The crude reaction is then filtered through a plug of silica, washed with EtOAc and the filtrate concentrated to give 2-(4-bromo-2-methyl-phenyl)-thiazole-5-carbaldehyde (3.8 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08530667B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-c12f0fcd0e9043199c989275ad5541f9 |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
