Hydrochloric Acid → 5,11-Dihydro-11-[1-oxo-2-methyl-6-(4-methyl-1-piperazinyl)-4-hexynyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
反応式
[O:1]=[C:2]([N:16]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[C:20](=[O:27])[NH:19][C:18]2[CH:28]=[CH:29][CH:30]=[N:31][C:17]1=2)[CH:3]([CH3:15])[CH2:4][C:5]#[C:6][CH2:7][N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]1.[ClH:32]>C(O)C>[ClH:32].[ClH:32].[O:1]=[C:2]([N:16]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[C:20](=[O:27])[NH:19][C:18]2[CH:28]=[CH:29][CH:30]=[N:31][C:17]1=2)[CH:3]([CH3:15])[CH2:4][C:5]#[C:6][CH2:7][N:8]1[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
28 g (0.067 mol) of 5,11-dihydro-11-[1-oxo-2-methyl-6-(4-methyl-1-piperazinyl)-4-hexynyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one are suspended in 350 ml of absolute ethanol and 45 ml of ethereal hydrochloric acid are added with stirring at boiling temperature. A clear solution is obtained at first, which goes cloudy again after some time. A fine crystal slurry is precipitated which is cooled and suction filtered and then washed with 50 ml of absolute ethanol and 150 ml of acetone.