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4-(4-Phenylpiperazin-1-yl)benzaldehyde → HCID 178516625、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(4-Phenylpiperazin-1-yl)benzaldehyde | HCID 12137503 | — |
| 反応物 | Tert-butyl malonate | HCID 21883978 | — |
| 反応物 | Sodium t-butoxide | HCID 23676156 | — |
| 反応物 | 1-Isocyano-2-methylpropan-2-yl methyl carbonate | HCID 25267464 | — |
| 反応物 | HCID 178507353 | HCID 178507353 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | HCID 178516625 | HCID 178516625 | — |
反応手順
The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (1.01 g, 8.27 mmol), 4-(4-phenylpiperazin-1-yl)benzaldehyde (2.2 g, 8.27 mmol), mono-tert-butyl malonate (1.98 g, 12.40 mmol), 1-isocyano-2-methylpropan-2-yl methyl carbonate (1.3 g, 8.27 mmol) in MeOH/CH2Cl2 1:1 (80 ml) with stirring for 4 days and sodium tert.-butoxide (1.0 g, 8.59 mmol) according to method 5.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08530670B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-f9dd198a4c854635863231dddc763e1d |
| 出典メモ | uspto-grants-2013_09 |