4-(4-Methylpiperazin-1-yl)benzaldehyde → HCID 178480647、化合物

HRID 41762

反応式

HRID 41762 の反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:11][N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=2)[CH2:14][CH2:13]1.[C:26](OC(C)(C)C)(=[O:31])[CH2:27][C:28]([O-])=[O:29].C(=O)(OC)OC(C)(C)C[N+]#[C-].CC(C)([O-])C.[Na+]>CO.C(Cl)Cl>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:22]([C:21]4[CH:24]=[CH:25][C:18]([N:15]5[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]5)=[CH:19][CH:20]=4)[C:28](=[O:29])[CH2:27][C:26]3=[O:31])=[CH:9][C:4]=2[N:3]=[CH:2]1

参加物

7

反応物 5

HCID 7365334-(4-Methylpiperazin-1-yl)benzaldehydeHCID 21883978Tert-butyl malonateHCID 23676156Sodium t-butoxideHCID 252674641-Isocyano-2-methylpropan-2-yl methyl carbonateHCID 178507353HCID 178507353、化合物

生成物 1

HCID 178480647HCID 178480647、化合物

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

The compound was synthesized starting from 1H-benzo[d]imidazol-5-amine (0.85 mg, 6.37 mmol), 4-(4-methylpiperazin-1-yl)benzaldehyde (1.3 g, 6.37 mmol), mono-tert-butyl malonate (1.53 g, 9.55 mmol), 1-isocyano-2-methylpropan-2-yl methyl carbonate (1.1 g, 7.01 mmol) in MeOH/CH2Cl2 1:1 (30 ml) with stirring for 2.5 days and sodium tert.-butoxide (0.235 g, 2.10 mmol) according to method 5.

後処理

  1. customThe compound was synthesized

出典と根拠

ORDレコード
ord-6cfc93dfe97b44509fdf6828efbfefa2
出典データセット
uspto-grants-2013_09
特許番号
US08530670B2

関連ノート

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