(Chlorothio)formyl chloride → 5-[2-(4-Hydroxy-3,5-di-tert-butylphenyl)ethyl]-1,3,4-oxathiazol-2-one

HRID 4177

反応式

HRID 4177 の反応式
[OH:1][C:2]1[C:7]([C:8]([CH3:11])([CH3:10])[CH3:9])=[CH:6][C:5]([CH2:12][CH2:13][C:14]([NH2:16])=[O:15])=[CH:4][C:3]=1[C:17]([CH3:20])([CH3:19])[CH3:18].Cl[C:22]([S:24]Cl)=[O:23]>C1(C)C=CC=CC=1>[OH:1][C:2]1[C:3]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:4][C:5]([CH2:12][CH2:13][C:14]2[O:15][C:22](=[O:23])[S:24][N:16]=2)=[CH:6][C:7]=1[C:8]([CH3:11])([CH3:10])[CH3:9]

参加物

4

反応物 2

HCID 75990(Chlorothio)formyl chlorideHCID 122714763-(3,5-Di-tert-butyl-4-hydroxyphenyl)propanamide

生成物 1

HCID 201529325-[2-(4-Hydroxy-3,5-di-tert-butylphenyl)ethyl]-1,3,4-oxathiazol-2-one

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
60 °C

実験手順

A suspension of 13.45 grams of 3-[4-hydroxy-3,5-di- tert-butylphenyl]propionamide in 150 ml of toluene is admixed with 20.22 grams of chlorocarbonyl sulfenyl chloride added dropwise. After heating the reaction mixture at 60° C. for 20 hours, the solvent is removed under reduced pressure. The residue is recrystallized from heptane to give the title compound as a pale yellow crystalline solid: mp 82°-86° C.

後処理

  1. additionadded dropwise
  2. customthe solvent is removed under reduced pressure
  3. customThe residue is recrystallized from heptane

出典と根拠

ORDレコード
ord-aceb139e08c74474b4660ef26669537f
出典データセット
uspto-grants-1988_02
特許番号
US04724246

関連ノート

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