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2-Bromo-5-fluorotoluene → 4-Fluoro-2-methylbenzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromo-5-fluorotoluene | HCID 96743 | — |
| 反応物 | HCID 178418546 | HCID 178418546 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Fluoro-2-methylbenzonitrile | HCID 3826055 | 60% |
反応手順
A mixture of 2-bromo-5-fluorotoluene (2) (3.5 g, 18.5 mmol) and CuCN (2 g, 22 mmol) in DMF (100 mL) was refluxed for 24 hours. The reaction was diluted with water and extracted with hexane. The organics were dried over MgSO4 and the solvent removed to give product 3 (yield 60%). 1H-NMR (400 MHz, CDCl3): δ 7.60 (dd, J=5.6, 8.8 Hz, 1H), 6.93-7.06 (m, 2H), 2.55 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08093236B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-cf5b6213d93942519cca961bdd767c9f |
| 出典メモ | uspto-grants-2012_01 |