Aminomalononitrile p-toluenesulphonate → HCID 178430961、化合物

HRID 418004

反応式

HRID 418004 の反応式
C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH2:12][CH:13]([C:16]#[N:17])[C:14]#[N:15].[CH:18](=[N:22][OH:23])[C:19]([CH3:21])=O>CC(O)C>[NH2:15][C:14]1[C:13]([C:16]#[N:17])=[N:12][C:19]([CH3:21])=[CH:18][N+:22]=1[O-:23]

参加物

4

反応物 2

HCID 563049Aminomalononitrile p-toluenesulphonateHCID 63992132-Oxopropanal-1-oxime

生成物 1

HCID 178430961HCID 178430961、化合物収率 90.2%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Aminomalononitrile p-toluenesulfonate salt (20.0 g, 79 mmol) and pyruvaldehyde 1-oxime (6.88 g, 79 mmol) were combined in a flask. iPrOH (140 mL) was added, and the resulting yellow slurry was allowed to stir at room temperature for 18 h, during which time a yellow precipitate accumulated. The mixture was filtered and the precipitate was washed with iPrOH (2×50 mL) and DI H2O (20 mL), then lyophilized to give 2-amino-3-cyano-5-methypyrazine N-oxide (10.7 g).

後処理

  1. filtrationThe mixture was filtered
  2. washthe precipitate was washed with iPrOH (2×50 mL) and DI H2O (20 mL)

出典と根拠

ORDレコード
ord-413b1cd18a144742a09ab32d88c2f064
出典データセット
uspto-grants-2012_01
特許番号
US08093244B2

関連ノート

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