Bromo-3-methanesulfonyl-5-(4-methoxy-benzyloxy)-benzene → 3-Bromo-5-(methylsulfonyl)phenol

HRID 418094ノート

反応式

HRID 418094 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([O:8]CC2C=CC(OC)=CC=2)[CH:5]=[C:4]([S:18]([CH3:21])(=[O:20])=[O:19])[CH:3]=1>C(O)(=O)C>[Br:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([S:18]([CH3:21])(=[O:19])=[O:20])[CH:3]=1

参加物

3

反応物 1

HCID 57863085Bromo-3-methanesulfonyl-5-(4-methoxy-benzyloxy)-benzene

生成物 1

HCID 578630913-Bromo-5-(methylsulfonyl)phenol収率 88.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
100 °C

実験手順

Bromo-3-methanesulfonyl-5-(4-methoxy-benzyloxy)-benzene (5.7 g) was dissolved in glacial acetic acid (80 mL) and stirred at 100° C. for 5 h. The solvent was removed under reduced pressure and the crude material was purified on a silica gel column using ethyl acetate and hexanes to yield the title compound (3.4 g, 88% yield).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe crude material was purified on a silica gel column

出典と根拠

ORDレコード
ord-512b7932333f46faa7caeaebb2c01175
出典データセット
uspto-grants-2012_01
特許番号
US08093253B2

反応ノート

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