関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,5-Dimethyl-1H-indole | HCID 70965 | — |
| 反応物 | 4-Chloro-8-methylquinoline | HCID 12326335 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 8-Methyl-(2,5-dimethyl-1H-indol-3-yl)quinoline | HCID 18729479 | 99.7% |
反応手順
2,5-Dimethylindole (290 mg) and 8-methyl-4-chloroquinoline (360 mg) were suspended in N-methylpyrolidinone (0.5 ml), and maintained under a nitrogen atmosphere. The reaction was heated to 140° C. with stirring for 45 minutes. On cooling a deep red precipitate formed, the mixture was diluted with diethylether and the solid collected by filtration, and dried to give the sub-title compound (570 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08093278B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-ae91cbb6e53f482bb788d4d9733ac7db |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
