2,5-Dimethyl-1H-indole → 6-Fluoro-4-(2,5-dimethyl-1H-indol-3-yl)quinoline

反応式

[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([CH3:11])=[CH:6][CH:5]=2.Cl[C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([F:23])[CH:21]=2)[N:16]=[CH:15][CH:14]=1>>[F:23][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][CH:19]=1)[N:16]=[CH:15][CH:14]=[C:13]2[C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:11])[CH:8]=2)[NH:3][C:2]=1[CH3:1]

参加物

反応物 2

HCID 709652,5-Dimethyl-1H-indole

HCID 27365864-Chloro-6-fluoroquinoline

生成物 1

HCID 666518606-Fluoro-4-(2,5-dimethyl-1H-indol-3-yl)quinoline

実験手順

The sub-title compound was prepared by the method of Example 10 part a, using 2,5-dimethyl indole and 4-chloro-6-fluoroquinoline.

出典と根拠

ORDレコード: ord-34ac9d985ace4c23a22f143bfdba9be7
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08093278B2

反応ノート

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