関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,5-Dimethyl-1H-indole | HCID 70965 | — |
| 反応物 | 4-Chloro-8-(trifluoromethyl)quinoline | HCID 90262 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-(2,5-Dimethyl-1H-indol-3-yl)-8-(trifluoromethyl)-quinoline, hydrochloride | HCID 131729345 | 67% |
反応手順
A mixture of 2,5-dimethylindole (765 mg) and 4-chloro-8-trifluoromethylquinoline (1.22 g) in NMP (1.5 ml) and 4M HCl in dioxane (0.2 ml) was heated at 140° C. for 1 h. After cooling the mixture was triturated with ether and filtered to give the sub-title compound (1.33 g) as a dark red solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08093278B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-3d83c96dcd864fa89b3975550fedd3df |
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| 出典メモ | uspto-grants-2012_01 |
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