Water → 2-(2,5-dimethyl-1H-indol-3-yl)-benzoxazole

HRID 418430ノート

反応式

HRID 418430 の反応式
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([CH3:11])=[CH:6][CH:5]=2.Cl[C:13]1[O:14][CH:15]=[CH:16][N:17]=1.CN1[C:23](=O)[CH2:22][CH2:21][CH2:20]1.O>CCOC(C)=O>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:13]1[O:14][C:15]3[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=3[N:17]=1)=[CH:8][C:7]([CH3:11])=[CH:6][CH:5]=2

参加物

6

反応物 4

HCID 962WaterHCID 13387N-methyl-2-pyrrolidoneHCID 709652,5-Dimethyl-1H-indoleHCID 133710742-Chloro-1,3-oxazole

生成物 1

HCID 684575182-(2,5-dimethyl-1H-indol-3-yl)-benzoxazole

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

2,5-dimethyl indole (0.3 g), 2-chlorooxazole (0.47 g) and NMP (2 ml) were heated in a microwave at 100 watts for 20 min at 160° C. Water ane EtOAc were added and separated, the aqueous phase was re-extracted with EtOAc (×4). The combined organic extracts were dried (MgSO4) and concentrated in vacuo. The precipitate was triturated with EtOAc then recrystallised from methanol to give the title compound (0.19 g).

後処理

  1. customseparated
  2. extractionthe aqueous phase was re-extracted with EtOAc (×4)
  3. dry with materialThe combined organic extracts were dried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customThe precipitate was triturated with EtOAc
  6. customthen recrystallised from methanol

出典と根拠

ORDレコード
ord-1c7720cdc9f248b9ade995052acb0d4c
出典データセット
uspto-grants-2012_01
特許番号
US08093278B2

反応ノート

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