関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4,7-Dichloroquinoline | HCID 6866 | — |
| 反応物 | 2-Methyl-5-nitro-1H-indole | HCID 280313 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | HCID 131729352 | HCID 131729352 | 95.6% |
反応手順
A mixture of 2-methyl-5-nitroindole (1.34 g) and 4,7-dichloroquinoline (1.53 g) in NMP (1 ml) and 4M HCl in dioxane (0.1 ml) was heated at 145° C. for 2 hours and at 160° C. for 4 hours. After cooling the mixture triturated with ether and the solid collected to give the sub-title compound (2.72 g) as a green solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08093278B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-8782189cd65e4c2b9bd14634dca9706f |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
