4,7-Dichloroquinoline → HCID 131729352、化合物

HRID 418439

反応式

HRID 418439 の反応式
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([N+:11]([O-:13])=[O:12])=[CH:6][CH:5]=2.[Cl:14][C:15]1[C:24]2[C:19](=[CH:20][C:21]([Cl:25])=[CH:22][CH:23]=2)[N:18]=[CH:17][CH:16]=1>CN1C(=O)CCC1.Cl.O1CCOCC1>[ClH:14].[Cl:25][C:21]1[CH:20]=[C:19]2[C:24]([C:15]([C:10]3[C:9]4[C:4](=[CH:5][CH:6]=[C:7]([N+:11]([O-:13])=[O:12])[CH:8]=4)[NH:3][C:2]=3[CH3:1])=[CH:16][CH:17]=[N:18]2)=[CH:23][CH:22]=1

参加物

6

反応物 2

HCID 68664,7-DichloroquinolineHCID 2803132-Methyl-5-nitro-1H-indole

生成物 1

HCID 131729352HCID 131729352、化合物収率 95.6%

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid溶媒HCID 13387N-methyl-2-pyrrolidone溶媒HCID 312751,4-Dioxane溶媒

反応条件

温度
160 °C

実験手順

A mixture of 2-methyl-5-nitroindole (1.34 g) and 4,7-dichloroquinoline (1.53 g) in NMP (1 ml) and 4M HCl in dioxane (0.1 ml) was heated at 145° C. for 2 hours and at 160° C. for 4 hours. After cooling the mixture triturated with ether and the solid collected to give the sub-title compound (2.72 g) as a green solid.

後処理

  1. temperatureAfter cooling the mixture
  2. customtriturated with ether
  3. customthe solid collected

出典と根拠

ORDレコード
ord-8782189cd65e4c2b9bd14634dca9706f
出典データセット
uspto-grants-2012_01
特許番号
US08093278B2

関連ノート

読み込み中…