Phosphorus oxychloride → 4-Chloro-8-(difluoromethoxy)quinoline
反応式
[F:1][CH:2]([F:15])[O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2O.P(Cl)(Cl)([Cl:18])=O>>[F:1][CH:2]([F:15])[O:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[Cl:18]参加物
3
実験手順
The product from step b) was heated to reflux in phosphorus oxychloride (80 ml) for 1 hour. The reagent was evaporated under reduced pressure to give an oil which was carefully poured into a mixture of ice/880 ammonia solution (400 ml) and stirred for 30 minutes. The solid was filtered off and dried in vacuo to give the sub-title compound (6.80 g).
後処理
- customThe reagent was evaporated under reduced pressure
- customto give an oil which
- filtrationThe solid was filtered off
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-b4394c2c00fa4d369689f08ced98c5be
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08093278B2
反応ノート
読み込み中…