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Toluene → 5-Chloro-2-methyl-3-(8-quinolinyl)-1H-indole-1-acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Lithium Chloride | HCID 433294 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Quinoline-7-boronic acid | HCID 21886457 | — |
| 触媒 | Tetrakis palladium triphenylphosphine | HCID 86600928 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Chloro-2-methyl-3-(8-quinolinyl)-1H-indole-1-acetic acid | HCID 10383271 | — |
反応手順
The product of part b (250 mg), 7-quinoline boronic acid (114 mg), 2M sodium bicarbonate (0.7 ml), toluene, ethanol, tetrakis palladium triphenyl phosphine (O) and lithium chloride were heated at reflux for 2 hours. The reaction mixture was concentrated in vacuo, purified using amine resin and then by reverse phase preparative HPLC to give the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08093278B2 |
| 出典データセット | uspto-grants-2012_01 |
| ORD ID | ord-fd2c68541ba04a9aa2532959621190bc |
| 出典メモ | uspto-grants-2012_01 |