Methanol → (R)-2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

反応式

[Cl:1][C:2]1[C:3]([N+:13]([O-:15])=[O:14])=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])O[CH:6]=[CH:5]2.CO.C(N(CC)CC)C.Cl.[NH2:26][C@H:27]([CH3:31])[C:28]([NH2:30])=[O:29]>>[Cl:1][C:2]1[C:3]([N+:13]([O-:15])=[O:14])=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:26]([C@H:27]([CH3:31])[C:28]([NH2:30])=[O:29])[CH:6]=[CH:5]2

参加物

反応物 4

HCID 887Methanol

HCID 8471Triethylamine

HCID 2775814(2R)-2-Aminopropanamide hydrochloride

HCID 595157256-Chloro-5-nitro-1H-isochromen-1-one

生成物 1

HCID 59515858(R)-2-(6-Chloro-5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

反応条件

温度: 55 °C

実験手順

To a solution of 6-chloro-5-nitro-1H-isochromen-1-one (950 mg, 0.0042 mol) in methanol (30 mL, 0.7 mol) was added triethylamine (0.64 mL, 0.0046 mol) and (R)-2-aminopropanamide hydrochloride (0.58 g, 0.0046 mol). The reaction was heated to 55° C. overnight and the solvent was removed under reduced pressure. The residue was purified by flash chromatography to afford the product as light yellow solid.

後処理

customthe solvent was removed under reduced pressure
customThe residue was purified by flash chromatography

出典と根拠

ORDレコード: ord-ad4264adc4504056827fada3c9089b58
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08093265B2

反応ノート

読み込み中…