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HRID 418576作成日：2026年10月26日

N1-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide → N1-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-phenylmalonamide

https://huagongshe.com/reaction/418576

反応式

関与物質

役割名称HCID仕込み量
反応物N1-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamideHCID 45488043—
反応物4-(2-(1-Ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamineHCID 59424455—
生成物N1-(4-(2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-N3-phenylmalonamideHCID 5695345157%

反応手順

Following the procedure described for compound 5a (example 1, step 5) but substituting amine 9 for compound 15, title compound 5d was obtained in 57% yield. MS (m/z): 516.0 (M+H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08093264B2
出典データセットuspto-grants-2012_01
ORD IDord-00695fe7c0bf4d7b8603aee107b5487f
出典メモuspto-grants-2012_01