P-Anisidine → 1-(2-Methoxyphenylcarbamoyl)cyclopropanecarboxylic acid

反応式

[C:1]1([NH:7][C:8]([C:10]2([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:16][O:17]C1C=CC(N)=CC=1>>[CH3:16][O:17][C:6]1[CH:5]=[CH:4][CH:3]=[CH:2][C:1]=1[NH:7][C:8]([C:10]1([C:13]([OH:15])=[O:14])[CH2:11][CH2:12]1)=[O:9]

参加物

反応物 2

HCID 7732P-Anisidine

HCID 190968711-(Phenylcarbamoyl)cyclopropanecarboxylic acid

生成物 1

HCID 550353091-(2-Methoxyphenylcarbamoyl)cyclopropanecarboxylic acid収率 68%

実験手順

Following the procedure described above for compound 161 (scheme 45), but replacing aniline for 4-methoxyaniline, title compound 175 was obtained in 68% yield. M/S (m/z): 236.0 (M+H).

出典と根拠

ORDレコード: ord-e1ac4d7e29694583bb39617726722f85
出典データセット: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08093264B2

反応ノート

読み込み中…