関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Vorinostat | HCID 5311 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | N-hydroxy-N'-phenyloctanediamide vorinostat | HCID 86620476 | — |
反応手順
The seed slurry is prepared by combining vorinostat-fine dry cake (97.8-116.3 g, 0.37-0.44 mol) and 50:50 (v/v) ethanol/water solution (1.0-1.2 L). Under a minimum of 15 psig pressure, the seed slurry is heated to 62-66° C., aged for about 0.5 hours and then cooled to 60-64° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08093295B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-d4c7e5345ea947cc9cfdf45ae08fffd3 |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
