1-(4-Fluorophenyl)-1H-indazol-4-amine → 4-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-1h-indazol-4-yl]amino}methyl)-4-methyl-2-pentanol

HRID 418797

反応式

HRID 418797 の反応式
[CH3:1][C:2]([C:12]1[C:20]2[O:19][CH2:18][CH2:17][C:16]=2[CH:15]=[CH:14][CH:13]=1)([CH3:11])[CH2:3][C:4]1([C:7]([F:10])([F:9])[F:8])[CH2:6][O:5]1.[F:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]2[C:36]3[CH:35]=[CH:34][CH:33]=[C:32]([NH2:37])[C:31]=3[CH:30]=[N:29]2)=[CH:24][CH:23]=1>>[O:19]1[C:20]2[C:12]([C:2]([CH3:11])([CH3:1])[CH2:3][C:4]([CH2:6][NH:37][C:32]3[CH:33]=[CH:34][CH:35]=[C:36]4[C:31]=3[CH:30]=[N:29][N:28]4[C:25]3[CH:26]=[CH:27][C:22]([F:21])=[CH:23][CH:24]=3)([OH:5])[C:7]([F:8])([F:10])[F:9])=[CH:13][CH:14]=[CH:15][C:16]=2[CH2:17][CH2:18]1

参加物

3

反応物 2

HCID 249380581-(4-Fluorophenyl)-1H-indazol-4-amine2 回HCID 577755187-[1,1-Dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuran

生成物 1

HCID 576159434-(2,3-Dihydro-1-benzofuran-7-yl)-1,1,1-trifluoro-2-({[1-(4-fluorophenyl)-1h-indazol-4-yl]amino}methyl)-4-methyl-2-pentanol

実験手順

Prepared similarly to Example 1 from racemic 7-{1,1-dimethyl-2-[2-(trifluoromethyl)-2-oxiranyl]ethyl}-2,3-dihydro-1-benzofuran (which may be prepared according to WO 04/063163) and 1-(4-fluorophenyl)-1H-indazol-4-amine (Intermediate 2).

出典と根拠

ORDレコード
ord-c6d7c164a2f5465a8f961e9f7900a1cd
出典データセット
uspto-grants-2012_01
特許番号
US08093281B2

関連ノート

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