Acetic Acid → HCID 11594031、化合物
反応式
O[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:20])[CH2:9][C:10]([C:12]1[CH:17]=[C:16](OC)[CH:15]=[CH:14][N:13]=1)=[O:11].C[C:22](O)=[O:23]>Cl.O>[CH3:22][O:23][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[O:11][C:2]3[C:3]([C:8](=[O:20])[CH:9]=2)=[CH:4][CH:5]=[CH:6][CH:7]=3)=[N:13][CH:14]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
1-(2-Hydroxy-phenyl)-3-(4-methoxy-pyridin-2-yl )-propane-1,3-dione (870 mg, 3.21 mmol) was dissolved in a mixture of 48% HCl (1 mL) and AcOH (10 mL) and heated at 100° C. for 1 h. The reaction mixture was cooled to rt, diluted with water and extracted with EtOAc. The organic layer was washed with water, brine, dried and concentrated to give 2-(5-methoxy-pyridin-2-yl)-chromen-4-one (794 mg, 98%).
後処理
- temperatureThe reaction mixture was cooled to rt
- extractionextracted with EtOAc
- washThe organic layer was washed with water, brine
- customdried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-436e22d634eb4299987872b49062138f
- 出典データセット
- uspto-grants-2012_01
- 特許番号
- US08093273B2
反応ノート
読み込み中…