Potassium Carbonate → 5-Chloro-2-(2-fluoro-6-methoxy-phenoxy)-3-nitro-pyridine

HRID 419044

反応式

HRID 419044 の反応式
Br[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([Cl:11])=[CH:4][N:3]=1.[O:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=1[OH:21])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:11][C:5]1[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]([O:21][C:15]2[C:14]([O:12][CH3:13])=[CH:19][CH:18]=[CH:17][C:16]=2[F:20])=[N:3][CH:4]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 2806812-Bromo-5-chloro-3-nitropyridineHCID 27373672-Fluoro-6-methoxyphenol

生成物 1

HCID 666488545-Chloro-2-(2-fluoro-6-methoxy-phenoxy)-3-nitro-pyridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of 2-bromo-5-chloro-3-nitropyridine (2.37 g, 10 mmol) was dissolved in 40 mL DMF was added of 2-methoxyl-6-fluorophenol (1.7 g 11.9 mmol) was added into the solution followed by potassium carbonate (2.76, 20 mmol). The mixture was stirred at room temperature for 5 h, then poured into ice water (200 mL). The precipitate was filtered and dried under high vacuum to provide 5-chloro-2-(2-fluoro-6-methoxy-phenoxy)-3-nitro-pyridine.

後処理

  1. additionwas added into the solution
  2. filtrationThe precipitate was filtered
  3. customdried under high vacuum

出典と根拠

ORDレコード
ord-8107ed1fb7e3439ea1c548acc436c627
出典データセット
uspto-grants-2012_01
特許番号
US08093247B2

関連ノート

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