Hydroxylamine → Benzyloxy-3-nitro[1,5]naphthyridin-4-amine

HRID 419282

反応式

HRID 419282 の反応式
[CH2:1]([O:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17](Cl)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([O:30][C:31]1[C:40]([N+:41]([O-:43])=[O:42])=[C:39](Cl)[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][N:37]=2)[N:32]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.NO>>[CH2:1]([O:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17]([NH2:32])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:23]([O:30][C:31]1[C:40]([N+:41]([O-:43])=[O:42])=[C:39]([NH2:10])[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][N:37]=2)[N:32]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

5

反応物 3

HCID 787HydroxylamineHCID 21075762Benzyloxy-4-chloro-3-nitroquinolineHCID 66650176Benzyloxy-4-chloro-3-nitro[1,5]naphthyridine

生成物 2

HCID 66649873Benzyloxy-3-nitro[1,5]naphthyridin-4-amineHCID 66649911Benzyloxy-3-nitroquinolin-4-amine

実験手順

In step (5) of Reaction Scheme I, a benzyloxy-4-chloro-3-nitroquinoline or benzyloxy-4-chloro-3-nitro[1,5]naphthyridine of Formula XIX is treated with an amino alcohol of formula HO—(CH2)c—CH2—NH2 to provide a benzyloxy-3-nitroquinolin-4-amine or benzyloxy-3-nitro[1,5]naphthyridin-4-amine of Formula XX. The reaction is conveniently carried out by adding the amino alcohol of formula HO—(CH2)c—CH2—NH2 to a solution of a compound of Formula XIX in a suitable solvent such as dichloromethane in the presence of a tertiary amine such as triethylamine. The reaction can be carried out at ambient temperature or at an elevated temperature such as, for example, the reflux temperature of the solvent. The reaction product can be isolated using conventional methods.

後処理

  1. customIn step (5) of Reaction Scheme I

出典と根拠

ORDレコード
ord-8e73153255434929bf0f88c1d544d9d9
出典データセット
uspto-grants-2012_01
特許番号
US08093390B2

関連ノート

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