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3-Hydroxyacetophenone → 3-[(E)-C-methyl-N-[(4-nitrophenyl)methoxy]carbonimidoyl]phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Hydroxyacetophenone | HCID 8487 | — |
| 反応物 | Hydroxylamine, O-((4-nitrophenyl)methyl)-, hydrochloride (1:1) | HCID 74967 | — |
| 生成物 | 3-[(E)-C-methyl-N-[(4-nitrophenyl)methoxy]carbonimidoyl]phenol | HCID 25100094 | 82% |
反応手順
3′-Hydroxyacetophenone (24) (150 mg, 1.10 mmol) was condensed with compound 19 (248 mg, 1.21 mmol) according to the general procedure II-A defined above. After being heated for 3 h the reaction mixture was cooled and the solvent removed under reduced pressure. The resulting solid was filtered off and washed with cold isopropanol (3.0 mL) to afford the title compound CP30260 (257 mg, 82%) as a white solid, m.p. 123.6-125.3° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536157B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-266b105a4a4f4cf9893712840d16ff93 |
| 出典メモ | uspto-grants-2013_09 |