関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 4-Bromo-2,5-difluoronitrobenzene | HCID 2736286 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Bromo-2-fluoro-5-methoxy-4-nitrobenzene | HCID 22347312 | 95.2% |
反応手順
To 1-bromo-2,5-difluoro-4-nitrobenzene (5.0 g, 21 mmol) was added 0.5 N sodium methoxide (50 mL, 25 mmol). The mixture was stirred at 60° C. for 1 h. The MeOH was rotovaped down. The crude product was dissolved in DCM (100 mL), washed with H2O, dried (Na2SO4), filtered, and rotovaped down to give the title compound of step A (5 g, 20 mmol, 95%) as a yellow solid. 1H NMR (400 MHz, CDCl3) δ ppm 7.69 (s, 1H), 7.28 (s, 1H), 3.95 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08093239B2 |
|---|
| 出典データセット | uspto-grants-2012_01 |
|---|
| ORD ID | ord-f3a7673b827643669d7dc4972db4a14c |
|---|
| 出典メモ | uspto-grants-2012_01 |
|---|
